Recent magnetic resonance imaging and pathological studies have indicated that axonal loss is a major contributor to disease progression in multiple sclerosis. 1 H magnetic resonance spectroscopy, through measurement of N -acetyl aspartate, a neuronal marker, provides a unique tool to investigate this. Patients with primary progressive multiple sclerosis have few lesions on conventional MRI, suggesting that changes in normal appearing white matter, such as axonal loss, may be particularly relevant to disease progression in this group. To test this hypothesis (...) NAWM was studied with MRS, measuring the concentration of N -acetyl derived groups. Single-voxel MRS using a water-suppressed PRESS sequence was carried out in 24 patients with primary progressive multiple sclerosis and in 16 age-matched controls. Ratios of metabolite to creatine concentration were calculated in all subjects, and absolute concentrations were measured in 18 patients and all controls. NA/Cr was significantly lower in NAWM in patients than in controls, as was the absolute concentration of NA. There was no significant difference in the absolute concentration of creatine between the groups. This study supports the hypothesis that axonal loss occurs in NAWM in primary progressive multiple sclerosis and may well be a mechanism for disease progression in this group. (shrink)

In this thesis I shall summarize and critically examine the central features of the theories of values of four contemporary moral philosophers: A.J. Ayer, C.L. Stevenson, R.M. Hare, and P.H. Nowell - Smith. I shall first look back, however, to the theory of moral philosophy of the most influential 'forefather' of this group, David Hume. Hume's theory stands as a challenge to moral philosophers who would assume that moral judgments are primarily, in some sense, acts of 'reason'. Although (...) our four contemporaries follow Hume in this, his challenge, in the form I shall indicate shortly, will provide the main theme for this thesis. (shrink)

The mass media promotes terrorism by stressing fear and an uncertain future. Major changes in US foreign and domestic policy essentially went unreported and unchallenged by the dominant news organizations. Notwithstanding the long relationship in the United States between fear and crime, the role of the mass media in promoting fear has become more pronounced since the United States `discovered' international terrorism on 11 September 2001. Extensive qualitative media analysis shows that political decision-makers quickly adjusted propaganda passages, prepared as part (...) of the Project for the New American Century, to emphasize domestic support for the new US role in leading the world. These messages were folded into the previous crime-related discourse of fear, which may be defined as the pervasive communication, symbolic awareness, and expectation that danger and risk are a central feature of everyday life. Politicians marshaled critical symbols and icons joining terrorism with Iraq, the Muslim faith, and a vast number of non-western nations to strategically promote fear and use of audience beliefs and assumptions about danger, risk and fear in order to achieve certain goals, including expanding domestic social control. (shrink)

The contours of the portrait of David contained in the Old Testament narratives can be recognized more clearly if they are seen in relation to a portrait composed in a medium other than words.

The goal of cladistic systematics is to discern sister-group relations (cladistic relations) by the methods of cladistic analysis and to represent them explicitly and unambiguously in cladograms and cladistic classifications. Cladists have selected cladistic relations to represent for two reasons: cladistic relations can be discerned with reasonable certainty by the methods of cladistic analysis and they can be represented with relative ease in cladograms and classifications. Cladists argue that features of phylogeny other than cladistic relations cannot be discerned with sufficient (...) certainty to warrant attempting to represent them in either cladograms or classifications and could not be represented if they could. I argue that a better alternative is to work toward improving methods of cladistic analysis (or else to supplement them with other methods) so that such features of phylogeny can be discerned and to devise methods of representation capable of representing them in both cladograms and classifications. However, cladograms and classifications cannot represent everything about phylogeny. It is better to represent one or two aspects of phylogeny explicitly and unambiguously than nothing at all. (shrink)

Theories in cognitive science, and especially cognitive neuroscience, often claim that parts of cognitive systems are reused for different cognitive functions. Philosophical analysis of this concept, however, is rare. Here, I first provide a set of criteria for an analysis of reuse, and then I analyse reuse in terms of the functions of subsystems. I also discuss how cognitive systems execute cognitive functions, the relation between learning and reuse, and how to differentiate reuse from related concepts like multi-use, redundancy, and (...) duplication of parts. Finally, I illustrate how my account captures the reuse of dynamical subsystems as unveiled by recent research in cognitive neurobiology. This recent research suggests two different evolutionary justifications for reuse claims. _1_ Introduction _2_ Criteria for Analyses of Reuse _3_ Use and Reuse _4_ The Reuse of Dynamical Systems in Cognitive Systems _5_ Conclusion. (shrink)

This study builds on prior research investigating the antecedents of firm supererogation. Examining vehicle recalls in the U.S. automobile industry from 1966 to 2010 reveals that surveillance-based government enforcement programs can have widespread industry effects on a specific type of supererogatory action, firm volunteerism. Specifically, increases in government surveillance are associated with firms going beyond what is legally required of them by initiating voluntary product recalls for defects not covered in existing government regulation. Such effects are shown to be unique (...) among surveillance efforts as other government enforcement activities, such as standards-based regulation, are revealed to have a negative association with firm supererogation. (shrink)

The question of what explains individual differences in expertise within complex domains such as music, games, sports, science, and medicine is currently a major topic of interest in a diverse range of fields, including psychology, education, and sports science, to name just a few. Ericsson and colleagues’ deliberate practice view is highly influential perspective in the literature on expertise and expert performance—but is it viable as a testable scientific theory? Here, reviewing more than 25 years of Ericsson and colleagues’ writings, (...) we document critical inconsistencies in the definition of deliberate practice, along with apparent shifts in the standard for evidence concerning deliberate practice. We also consider the impact of these issues on progress in the field of expertise, focusing on the empirical testability and falsifiability of the deliberate practice view. We then discuss a multifactorial perspective on expertise, and how open science practices can accelerate progress in research guided by this perspective. (shrink)

Certain lines of reasoning common in evolutionary taxonomy have been termed viciously circular. They are quite obviously not logically circular. They do give the superficial appearance of epistemological circularity. This appearance arises from the method of successive approximation used by evolutionary taxonomists. It is argued that this method is not epistemologically circular, even when the only evidence that the taxonomist has to go on is the phenetic similarity of contemporary forms. The important criticism of evolutionary taxonomy is rather that in (...) the absence of fossil evidence phyletic reconstructions are not warranted. It is argued that this charge stems initially from a misunderstanding of the kind of certainty possible in empirical science. When this criticism is couched in appropriate terms, it may be seen to have some force. Many phyletic inferences are not as warranted as one might wish. However, there is a great deal of difference between arguing that a line of reasoning is unwarranted and arguing that it is viciously circular. (shrink)

Criticized as a nostalgic anachronism by those who oppose her version of political theory and lauded as symbol of direct democratic participation by those who favor it, the Athenian polis features prominently in Hannah Arendt's account of politics. This essay traces the origin and development of Arendt's conception of the polis as a space of appearance from the early 1950s onward. It makes particular use of the Denktagebuch, Arendt's intellectual diary, in order to shed new light on the historicity of (...) one of her central concepts. The article contends that both critics and partisans of Arendt's use of the polis have made the same mistake: they have presumed that the polis represents a space of face-to-face immediacy. In fact, Arendt compared the polis to a series of analogues, many of which are not centered on direct exchanges between political actors and spectators. As a result, Arendt's early work on the polis turns out to anticipate many of the concerns of her later work on judgment, and her theory of the polis becomes a theory of topics. (shrink)

The way the brain, body, and mind interact with social structure to shape communication has so far not received the attention it deserves. This book addresses this gap by providing a novel account of communication as a social, biological and neurological force. Combining theories from communication studies and psycholinguistics, and drawing on biological and evolutionary perspectives, it shows how communication is inherently both biological and social, and that language and the neural systems that support it have evolved in response to (...) a complex social environment. It introduces a clear set of terms based on current research, and illustrates key concepts using real-life examples from everyday conversation - speaking to a number of current debates around the evolutionary and biological basis of language, and the relationship between language, cognition, and environment. Thought provoking and engaging, it will change the way we think about the relationship between communication and cognition. (shrink)

Exactly how do the sign/symbol/token systems of endo- and exo-biosemiosis differ from those of cognitive semiosis? Do the biological messages that integrate metabolism have conceptual meaning? Semantic information has two subsets: Descriptive and Prescriptive. Prescriptive information instructs or directly produces nontrivial function. In cognitive semiosis, prescriptive information requires anticipation and “choice with intent” at bona fide decision nodes. Prescriptive information either tells us what choices to make, or it is a recordation of wise choices already made. Symbol systems allow recordation (...) of deliberate choices and the transmission of linear digital prescriptive information. Formal symbol selection can be instantiated into physicality using physical symbol vehicles (tokens). Material symbol systems (MSS) formally assign representational meaning to physical objects. Even verbal semiosis instantiates meaning into physical sound waves using an MSS. Formal function can also be incorporated into physicality through the use of dynamically-inert (dynamically-incoherent or -decoupled) configurable switch-settings in conceptual circuits. This paper examines the degree to which biosemiosis conforms to the essential formal criteria of prescriptive semiosis and cybernetic management. (shrink)

Henry Thoreau boasted that he was widely travelled in Concord, Massachusetts. He was born there on 12 July 1817, and he died there on 6 May 1862, of tuberculosis, at the age of forty-four years. In 1837 he graduated from Harvard College, and in 1838 he joined Ralph Waldo Emerson, Margaret Fuller, and others in the informal group that became known as the New England Transcendentalists. The author of four books, many essays and poems, and a voluminous journal, he is (...) best known for the book Walden and the essay ‘Civil Disobedience’, and for the circumstances attending these two milestones in American thought and literature. (shrink)

"Legend is overdue for replacement, and an adequate replacement must attend to the process of science as carefully as Hull has done. I share his vision of a serious account of the social and intellectual dynamics of science that will avoid both the rosy blur of Legend and the facile charms of relativism.... Because of [Hull's] deep concern with the ways in which research is actually done, Science as a Process begins an important project in the study of science. It (...) is one of a distinguished series of books, which Hull himself edits."—Philip Kitcher, Nature "In Science as a Process, [David Hull] argues that the tension between cooperation and competition is exactly what makes science so successful.... Hull takes an unusual approach to his subject. He applies the rules of evolution in nature to the evolution of science, arguing that the same kinds of forces responsible for shaping the rise and demise of species also act on the development of scientific ideas."—Natalie Angier, New York Times Book Review "By far the most professional and thorough case in favour of an evolutionary philosophy of science ever to have been made. It contains excellent short histories of evolutionary biology and of systematics (the science of classifying living things); an important and original account of modern systematic controversy; a counter-attack against the philosophical critics of evolutionary philosophy; social-psychological evidence, collected by Hull himself, to show that science does have the character demanded by his philosophy; and a philosophical analysis of evolution which is general enough to apply to both biological and historical change."—Mark Ridley, Times Literary Supplement "Hull is primarily interested in how social interactions within the scientific community can help or hinder the process by which new theories and techniques get accepted.... The claim that science is a process for selecting out the best new ideas is not a new one, but Hull tells us exactly how scientists go about it, and he is prepared to accept that at least to some extent, the social activities of the scientists promoting a new idea can affect its chances of being accepted."—Peter J. Bowler, Archives of Natural History "I have been doing philosophy of science now for twenty-five years, and whilst I would never have claimed that I knew everything, I felt that I had a really good handle on the nature of science, Again and again, Hull was able to show me just how incomplete my understanding was.... Moreover, [Science as a Process] is one of the most compulsively readable books that I have ever encountered."—Michael Ruse, Biology and Philosophy. (shrink)

Here we will discuss the necessary relationship between both prediction and human behavior and meaning and human behavior. The main assumption upon which our thesis rests is that knowing is for the sake of acting and that, consequently, the symbolic process is continuous with overt bodily behavior and with the environment of the knower. A corollary to this assumption is: the locus of meaning is in behavior. Possibly after reading the article it will be clear that meanings presuppose conduct of (...) which we can take cognizance, and that there is a difference between behaving and taking cognizance of behavior. And although the locus of meaning is in behavior, meanings emerge only in relation to the symbolic process. In a sense we suffer, endure, live through behavior, but in the bare suffering of it there may be no meaning, for meaning requires also the symbolic process. (shrink)

The author proposes a system of identification, positional, and phyletic numbers for taxa that makes possible a significant relationship between numerical classification and phylogeny.

Drawing on work of the past decade, this volume brings together articles from the philosophy, history, and sociology of science, and many other branches of the biological sciences. The volume delves into the latest theoretical controversies as well as burning questions of contemporary social importance. The issues considered include the nature of evolutionary theory, biology and ethics, the challenge from religion, and the social implications of biology today (in particular the Human Genome Project).

Compares classic and contemporary theories of genetics and evolution and explores the role of teleological thought in biology.

In 2013, controversy sparked student protests, campus debates, and national attention when Smith College denied admittance to Calliope Wong—a trans woman. Since then, eight women’s colleges have revised their admissions policies to include different gender identities such as trans women and genderqueer people. Given the recency of such policies, we interrogate the ways the category “woman” is determined through certain alignments of biology-, legal-, and identity-based criteria. Through an inductive analysis of administrative scripts appearing both in student newspapers and in (...) trans admittance policies, we highlight two areas U.S. women’s colleges straddle while creating these policies: inclusion/exclusion scripts of self-identification and legal documentation, and tradition-/activism-speak. Through these tensions, women’s college admittance policies not only construct “womanhood” but also serve as regulatory norms that redo gender as a structuring agent within the gendered organization. (shrink)

Current debates over multiculturalism often pit those who believe that every perspective should be represented against those who hold fast to the notion of a universal "common ground." In this timely and original work, David L. Norton persuasively argues for the power of a "transcendental imagination," that is, an imagination that can go beyond itself to gain another's perspective without necessarily assimilating that perspective. Imagination, Understanding, and the Virtue of Liberality will be an important work for all intellectuals and (...) very useful in courses that address multiculturalism. (shrink)

Biological species have been treated traditionally as spatiotemporally unrestricted classes. If they are to perform the function which they do in the evolutionary process, they must be spatiotemporally localized individuals, historical entities. Reinterpreting biological species as historical entities solves several important anomalies in biology, in philosophy of biology, and within philosophy itself. It also has important implications for any attempt to present an "evolutionary" analysis of science and for sciences such as anthropology which are devoted to the study of single (...) species. (shrink)

The idea of self-knowledge divides naturally into two parts in accordance with the distinction between knowledge by acquaintance and knowledge by description. I know myself and I know things about myself. The latter I know partly from self-acquaintance, partly from the behavior, especially linguistic, of others, and partly from each of these. All aspects of self-knowledge are controversial, so I shall concentrate in this paper on the question of self-acquaintance. My purpose is both philosophical and historical. It is commonly believed (...) that Hume and Descartes held diametrically opposed, or at least strongly contrasting, views regarding self-acquaintance since Hume is regularly ridiculed for his denial of ability to discover his own Self whereas it would occur to no one to ascribe that same view to the author of the Meditations. In this paper I shall argue that contrary to appearances these two philosophers either held the same position or Descartes occupied the more agnostic extreme; and also that the position usually ascribed to Hume is, when properly understood, both correct and of fundamental philosophical significance. Part of my reason for selecting Hume and Descartes for analysis and comparison is to show thereby that the thesis of this paper is true independently of the rationalist/empiricist schism in philosophy. (shrink)